Endocrine Abstracts

Introduction: Central pontine myelinolysis (CPM) is a rare and potentially life-threatening complication of a sudden rise in serum osmolality. Along with extrapontine myelinolysis, it is part of the osmotic demyelination syndrome (ODS). Known risk factors include severe hyponatremia, alcoholism, thiazide use, hypokalemia, and malnourishment.Case report: We report the case of a 31-year-old-male with history of alcohol and cannabis dependence, who had atte...

Background: A systematic literature review (SLR) was conducted to assess the use of independent injections (self/partner/home-administered) as an alternative to healthcare-setting injections for chronic diseases. The primary objective was to identify studies reporting on independent injection of somatostatin analogues (SSAs). Comparative evidence on independent injection of other medications was examined as a secondary objective.Methods: MEDLINE/Embase/t...

Background: Acromegaly is a rare disorder characterized by excess growth hormone (GH) and insulin-like growth factor 1 (IGF-1). Extended dosing intervals (EDIs) of pharmacological treatments may reduce patient burden and costs compared with standard dosing. This systematic literature review (SLR) investigated treatment of acromegaly at EDIs.Methods: MEDLINE/Embase/the Cochrane Library (2001–June 2021) and key congresses (2018–2021) were searche...

Introduction: For the clinical diagnosis of heterozygous familial hypercholesterolemia (HeFH) validated algorithms are used, with the Dutch Lipid Clinic Network (DLCN) Criteria being the most recommended in our environment. One of the items that scores for the system proposed by the DLCN is the value of LDL cholesterol. However, LDLc levels can be distorted by lipoprotein a (Lpa(a)) levels.Objective: To analyze the change in the validity of the DLCN crit...

The use of Flash Glucose Monitoring system (FGM) for the management of type 1 diabetes mellitus (T1D) is rapidly increasing. FGM enables people with diabetes to regularly track their glucose levels without needing to perform capillary finger-stick measurements (SMBG). Clinical studies have shown improvement of glycemic control and hypoglycemia reduction, as well as better comfort and quality of life in people with type 1 diabetes (T1D) using this technology. Objectives: to ass...

Background: Genotype-phenotype correlations between various RET mutations and clinical manifestations of MEN 2 syndrome are well established. A discussion is still open if the FMTC phenotype really exists or if it is just a MEN2A variant. Aim of this study was to verify if the phenotype corresponding to the V804M germline mutation is restricted to FMTC.Methods: During the last 25 years, we have identified 200 families with a hereditary form of M...

Background: The last American Thyroid Association guidelines (ATA-2015) defined the risk of structural recurrence in patients with DTC cured after initial treatment and according to the initial histology. However, these data resulted from several studies including different patients with different kinds of treatment. We retrospectively evaluated a large population of patients with DTC, treated and followed in a tertiary referral center, with the aim to characterize the rate of...

Introduction: Virtually all familial cases of Medullary Thyroid Carcinoma (MTC) have a RET germline mutation. Subjects harboring RET germline mutation without unaware of their condition are defined gene carriers (GC). Thyroid surgery timing is decided upon RET mutation and calcitonin levels (both basal, bCT, and stimulated, sCT). However, bCT and sCT thresholds for planning thyroid surgery have not been established, yet.Methods...

Background: Acquired hypoparathyroidism due to thyroid surgery for thyroid cancer is the most common postsurgical etiology in a tertiary health center in Ecuador. Therefore, the data published from our country is limited. An observational cross-sectional study was carried out to determine the clinical, biochemical and therapeutic characteristics of patients with permanent hypoparathyroidism in the endocrinology department.Results: 102 patients were inclu...

Background: In patients affected with type 2 diabetes mellitus (T2DM) a high prevalence of hypogonadism has been reported, even if there is no consensus on its metabolic and cardiovascular implications, especially according to the type of hypogonadism. The aim of this observational study is to evaluate: (1) the prevalence of different types of hypogonadism in T2DM according to validated criteria from the EMAS study; (2) look for correlations of gonadal status with severity or ...